**Product Overview**
Manufacturer: Zeria Shinyaku Kogyo
Product Name: Esbyan S 12 mL
Pharmaceutical Classification: Class 3 OTC Drug
Category: OTC Medicine
Pediatric Use Category: Suitable for both adults and children
Dosage Form: Drink / Liquid
Content Volume: 12 mL
Product Description: For those who experience eye fatigue despite no eye abnormalities (diseases), and for individuals whose professions require especially intense eye use.

**Expiration Date**
At the time of shipment, the product has at least one year remaining until the expiration date.
JAN Code: 4987103051923
Product Code: 074801664

**Initial Package Insert Creation Date and Revision Date, Version Number**
Initial Creation: —
Revised: —

**Features**
There are several vitamins necessary for eye health, but especially the role of Vitamin B2 is important.
A deficiency in Vitamin B2 can lead to decreased function (metabolism) of the entire eye tissue, resulting in increased eye fatigue and a higher susceptibility to eye diseases.

Vitamin B2 exists in several forms, but the form used in this product, Flavin Adenine Dinucleotide Sodium (FAD), is called a coenzyme form of B2 and is more effective when applied as eye drops compared to regular B2.

Esbyan S primarily contains FAD, along with Vitamin B6, which enhances the nutrition of the retina and cornea; chondroitin, which protects eye tissue and maintains corneal transparency; and allantoin, which has healing effects.

**Features**
*Esbyan S is suitable for:*
- People who experience eye fatigue despite no eye abnormalities (diseases)
- Individuals with professions that heavily strain the eyes
- Drivers and others who use their eyes at night
- People who are prone to immediate eye redness
- Those with severe eye discharge or conjunctivitis
- People who wear contact lenses and are prone to inflammation of the cornea and other areas

**Precautions for Use**
1. Consult a doctor, pharmacist, or registered salesperson before use if you are:
(1) Under medical treatment.
(2) Have experienced allergic reactions to medicines or other products.
(3) Experiencing severe eye pain.
(4) Diagnosed with glaucoma.

2. If any of the following symptoms appear after use, discontinue immediately and consult a doctor, pharmacist, or registered salesperson with this document, as side effects may occur:
*Related areas and symptoms:*
- Skin: Rash, redness, itching
- Eyes: Conjunctival redness, itching, swelling

3. Discontinue use and consult a healthcare professional if:
(1) The eye fog does not improve.
(2) Symptoms do not improve after about two weeks of use.

**Indications and Effects**
- Eye fatigue
- Conjunctival hyperemia (redness)
- Blepharitis (eyelid inflammation)
- Prevention of eye diseases (e.g., after swimming, when dust or sweat enters the eyes)
- Eye fog (excessive eye discharge)
- Itching of the eyes
- Inflammation caused by ultraviolet or other light (e.g., snow blindness)
- Discomfort when wearing hard contact lenses

**Directions for Use and Dosage**
Apply 1 to 2 drops per use, 3 to 6 times daily.

*Related precautions:*
(1) When used by children, use under the guidance and supervision of a guardian.
(2) Do not let the tip of the container touch the eyes, eyelids, or eyelashes. Do not use if the solution is cloudy.
(3) Do not use while wearing soft contact lenses.
(4) For ophthalmic use only.
(5) Follow the prescribed usage and dosage.
(6) The liquid color is due to the ingredients. Be careful not to stain clothing or other items during application. If it gets on clothing, wash immediately with water.

**Ingredients and Amounts (per 10 mL)**
- Flavin Adenine Dinucleotide Sodium: 0.02%
- Pyridoxine Hydrochloride: 0.01%
- Sodium Chondroitin Sulfate Ester: 0.1%
- Allantoin: 0.1%

**Storage and Handling Precautions**
1. Store in a cool, shaded place away from direct sunlight, tightly sealed.
2. Keep out of reach of children.
3. Do not transfer to other containers (may cause misuse or change in quality).
4. Do not share with others.
5. Do not use products past the expiration date. Even if unopened, use promptly after opening.
6. Depending on storage conditions, crystals of the ingredients may form at the tip of the container. If this occurs, gently wipe with a clean gauze before use.

**Contact Information**
Zeria Shinyaku Kogyo Co., Ltd. Customer Consultation Office
Address: 10-11 Nihonbashi Kobunacho, Chuo-ku, Tokyo 103-8351
Phone: 03-3661-2080
Hours: 9:00–17:50 (excluding Saturdays, Sundays, and holidays)

**Manufacturer**
Zeria Shinyaku Kogyo

**Content Volume**
12 mL

**Suggested Retail Price**
715 yen (tax included)

**OTC Drug Classification**
Class 3 OTC Drug

**Poison and Quasi-Drug Category**
Not classified as poison or quasi-drug

**Pesticide/Animal Drug Category**
Not classified as pesticide or animal drug

**Dosage Form Category**
Internal liquid medicine

**Pediatric Use Category**
Suitable for both adults and children

**Product Category**
OTC medicine

**Disclaimer**
【Notice】
- The product description above, excluding price information, is provided by the manufacturer or the Self-Medication Database Center.
- If you have any questions or concerns about using this medicine, be sure to consult a doctor or pharmacist.
- We assume no responsibility for health damages caused by taking medicines purchased through this service.