【Category III OTC Drug】
**Product Details**

**Features**
- "Creston" is a medication that improves high serum cholesterol levels and alleviates peripheral circulatory disorders associated with high serum cholesterol (such as coldness and numbness in the hands and feet).
- The soybean-derived component "de-esterified soybean oil" suppresses the absorption of excess cholesterol from the intestines and promotes its excretion.
- Pantethine improves cholesterol metabolism in the liver. It promotes the breakdown of LDL ("bad" cholesterol), increases HDL ("good" cholesterol), removes excess cholesterol from the blood, and suppresses its deposition on blood vessel walls.
- Natural vitamin E (d-α-tocopherol acetate) inhibits the formation of lipid peroxides, smooths the blood, and alleviates peripheral circulatory disorders (such as coldness and numbness in the hands and feet).
"Creston" exerts its effects through the combined power of these three active ingredients.

High cholesterol often has no symptoms and is difficult to notice on your own.
It is recommended to regularly measure cholesterol levels at a medical facility after taking this product.

**Precautions for Use**
**Consultation before use**
1. Please consult a doctor, pharmacist, or registered seller before taking if you are:
(1) Under medical treatment.
(2) Have experienced allergic reactions to medicines or other products.
2. If any of the following symptoms appear after taking, there is a possibility of side effects. Discontinue use immediately and consult a doctor, pharmacist, or registered seller with this instruction manual.
- Skin: Rash, redness, itching
- Digestive system: Nausea, stomach discomfort, heartburn, loss of appetite, abdominal pain
3. If the following symptoms occur or worsen, stop taking the product and consult a healthcare professional:
- Diarrhea, soft stools
4. If no improvement in symptoms or cholesterol levels is observed after about one month of use, discontinue and consult a healthcare professional.
- After about one month of use, have cholesterol levels measured at a medical facility.
5. Menstrual periods may come earlier than expected or bleeding may be slightly heavier.
- If bleeding continues for a long time, consult a healthcare professional.

**Indications and Effects**
- Improvement of high serum cholesterol levels
- Relief of peripheral circulatory disorders (such as coldness and numbness in the hands and feet) associated with high serum cholesterol

**Usage and Dosage**
**Method of Use / Dosage**
- Take the following amount after meals with water or warm water.
- Age: Adults (15 years and older): 2 capsules, 3 times a day
- Under 15 years: Do not take

**Precautions regarding usage and dosage**
1. Strictly adhere to the prescribed usage and dosage.
2. Since dietary therapy is important for improving high serum cholesterol, continue dietary management even while taking this medication.

**Ingredients and Quantities**
**Contents and amounts per adult daily dose (6 capsules):**
- Pantethine: 375 mg
- De-esterified soybean oil: 600 mg
- d-α-tocopherol acetate: 100 mg

**Additives:** Safflower oil, Polysorbate 80, Glycerin, Titanium dioxide, Sunset Yellow FCF, Gelatin, D-sorbitol

**Storage and Handling Precautions**
1. Store in a cool, dry place away from direct sunlight. Always tightly close the bottle cap after use.
2. Keep out of reach of children.
3. Do not transfer to other containers (may cause misuse or change in quality).
4. Do not take products past the expiration date.

**Contact Information**
For inquiries about this product, please contact the pharmacy or drugstore where purchased or the following "Customer Consultation Office."
Kusumoto Pharmaceutical Co., Ltd. Customer Consultation Office
Phone: 0120-133250
Hours: 9:00 - 17:50 (excluding weekends, holidays, and company holidays)

**Manufacturer and Distributor**
- Brand Name: Creston
- Manufacturer: Tokai Capsule Co., Ltd.
- Product Size: 168 capsules
- Regulatory Category: General OTC drug
- Outer dimensions (mm): 54 (W) × 106 (H) × 54 (D)
- Weight: 210 g

*Note: Packaging and contents are subject to change without notice due to renewal.*

**Advertising Responsibility:**
Akakabe Co., Ltd.
Phone: 072-878-1375